Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24 Clinical Trial Not Allowed) | RFA AT 24 007

Opportunity Information: Apply for RFA AT 24 007

This funding opportunity is a limited-competition NIH grant (R24; clinical trials not allowed) focused on continuing and strengthening an already-established research resource for nuclear magnetic resonance (NMR) data on natural products. Led by the National Center for Complementary and Integrative Health (NCCIH) in partnership with the NIH Office of Dietary Supplements (ODS), the core goal is to support an online-capable resource that houses both raw NMR data and the associated metadata for a wide range of natural product materials, from complex crude extracts all the way to purified compounds. The resource is expected to provide practical functionality for the research community, specifically the ability to upload, download, store, search, and analyze raw NMR datasets, so that researchers can more easily compare spectra, verify identities, assess quality, and reuse data across studies.

The main purpose of the recompetition is not to start a brand-new database from scratch, but to ensure the sustainability and long-term usability of an existing NMR data resource. The NOFO emphasizes scaling and wider community inclusiveness, meaning the funded project should be positioned to serve more users, accommodate growth in volume and diversity of datasets, and broaden participation across the natural products community. In practice, that points to strengthening infrastructure, improving user access and discoverability, enhancing data standards and metadata quality, and ensuring the resource remains stable and maintainable over time. Because the mechanism is an R24 (research resource), the emphasis is on enabling and accelerating many downstream research efforts rather than producing a single hypothesis-driven research finding.

This opportunity sits within the broader Consortium Advancing Research on Botanicals and Other Natural Products (CARBON) Program. CARBON also includes complementary award types aimed at natural product science, including the Botanical Dietary Supplements Translational Research Teams (RM1) and projects focused on leveraging big data to understand natural product impacts on whole person health (R01). In that context, this R24 resource functions like shared infrastructure that can support the rest of the program and the field more broadly by making high-quality NMR reference and experimental data easier to access and reuse.

Administratively, the opportunity is issued by the National Institutes of Health under Funding Opportunity Number RFA-AT-24-007, categorized as a discretionary grant in the health activity area, with CFDA numbers 93.213 and 93.321. The listed award ceiling is $350,000, and the original application due date was July 8, 2024 (with the posting created March 14, 2024). The eligible applicant pool is broad and includes many types of U.S. government entities (state, county, city/township, special district), independent school districts, public housing authorities/Indian housing authorities, a wide range of higher education institutions (public/state-controlled and private), nonprofit organizations with or without 501(c)(3) status, for-profit organizations (other than small businesses), small businesses, and tribal governments or tribal organizations (including federally recognized tribes and other tribal entities). The announcement also explicitly highlights additional eligible groups such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), faith-based or community-based organizations, eligible federal agencies, U.S. territories or possessions, regional organizations, and even non-U.S. (foreign) organizations.

Finally, the “clinical trial not allowed” designation signals that the work proposed under this grant must remain focused on building and operating the NMR data resource rather than testing interventions in human subjects. The expected outcome is a more durable, scalable, and broadly used NMR data platform that improves transparency, reproducibility, and efficiency in natural products research by making raw spectra and well-curated metadata findable and usable by the wider scientific community.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Research Resource for Natural Product Nuclear Magnetic Resonance Data (R24 Clinical Trial Not Allowed)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.213, 93.321.
• This funding opportunity was created on 2024-03-14.
• Applicants must submit their applications by 2024-07-08. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $350,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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