Opportunity Information: Apply for RFA HL 23 005
The NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional), Funding Opportunity Number RFA-HL-23-005, is a discretionary NIH grant mechanism from the National Heart, Lung, and Blood Institute (NHLBI) within the U.S. Department of Health and Human Services. It is designed to provide long-term, flexible support to established, high-performing investigators working in heart, lung, blood, and sleep (HLBS) research. Unlike many NIH opportunities that focus on a narrowly defined project with specific aims tied tightly to a fixed plan, this award is meant to fund an investigator's broader research program. In practical terms, NHLBI is signaling that it wants to invest in people and their sustained trajectory of discovery, not just a single set of experiments.
A central goal of the EIA is to increase scientific productivity and spark innovation by giving investigators the time horizon and budget stability to pursue more ambitious ideas. The award supports research programs for up to seven years, which is a major feature because it enables longer planning cycles, continuity for personnel, and room for iterative exploration that is often hard to accommodate under shorter awards. The EIA explicitly aims to provide increased flexibility, allowing funded investigators to pivot as new findings emerge, extend earlier discoveries in new directions, and pursue higher-risk research that may require a longer runway before results are fully realized. The clinical trial optional designation indicates that applicants may propose studies that include clinical trials if appropriate, but they are not required to do so.
Eligibility is aimed at experienced Program Directors/Principal Investigators (PD/PIs) who are already demonstrating strong momentum and leadership in HLBS science. A key eligibility requirement highlighted in the opportunity description is that applicants must currently be the PD/PI on at least two NHLBI R01-equivalent awards. This requirement positions the EIA as a next-step, consolidating-style award for investigators who have already built a robust NHLBI-funded portfolio and have an outstanding record indicating they are likely to make major ongoing contributions to the field. Another important feature is that the EIA is intended to serve as the primary, and most likely the sole, source of NHLBI individual grant support for the investigator during the award period. That emphasis reflects a programmatic intent to streamline an investigator's NHLBI funding into one larger, longer award that supports a cohesive program rather than multiple separate R01-style projects.
The scientific scope must fall squarely within the NHLBI mission, meaning the proposed program needs to align with NHLBI's priorities across cardiovascular, pulmonary, hematologic, and sleep-related research domains. While the summary does not list specific topic areas beyond HLBS and mission alignment, the explicit mission requirement means the institute expects the overall program to advance understanding, prevention, diagnosis, and/or treatment relevant to these health areas in ways consistent with NHLBI's strategic interests.
From a funding standpoint, the opportunity lists an award ceiling of $700,000 (as provided in the source data) and anticipates making about 20 awards. As an NIH grant (Funding Instrument Type: Grant; Funding Activity Category: Health), this opportunity is cataloged under CFDA numbers 93.233, 93.837, 93.838, 93.839, and 93.840, reflecting its placement within NIH assistance listings tied to NHLBI and related research support lines.
The eligible applicant organizations span a wide range of entities, which is typical for NIH funding, including state, county, and local governments; special district governments; independent school districts; public and private institutions of higher education; nonprofit organizations with and without 501(c)(3) status; federally recognized Native American tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; for-profit organizations other than small businesses; small businesses; and other organizations as described in the full eligibility text. Even with broad institutional eligibility, the practical gatekeeper for this award is the PD/PI-level requirement of holding at least two NHLBI R01-equivalent awards and demonstrating an exceptional research record.
Key administrative details in the source data include a creation date of May 5, 2021, and an original closing date of April 25, 2024. Overall, the EIA is best understood as a long-duration, program-focused NHLBI award that gives proven investigators the flexibility to innovate, take calculated risks, and drive forward a cohesive HLBS research agenda with fewer constraints than traditional project-specific grants.Apply for RFA HL 23 005
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "NHLBI Emerging Investigator Award (EIA) (R35 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840.
- This funding opportunity was created on May 05, 2021.
- Applicants must submit their applications by Apr 25, 2024. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $700,000.00 in funding.
- The number of recipients for this funding is limited to 20 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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