Opportunity Information: Apply for RFA CK 20 004

The Prevention Epicenters Program: Protecting Patients from Infections, Antibiotic Resistance and Other Adverse Events is a CDC funding opportunity designed to build and sustain a collaborative research network focused on improving patient safety across U.S. healthcare settings. The central idea is to connect and coordinate experts who work on healthcare-associated infections (HAIs) and antibiotic resistance (AR) so they can rapidly respond to research priorities that matter most for protecting patients. Through this shared infrastructure, the program aims to move promising findings from basic science, epidemiology, and technology into practical, evidence-based strategies that prevent infections, slow the spread of resistant organisms, and reduce other harmful events that occur during healthcare.

This opportunity is offered by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC), and is administered through the CDC electronic research administration (ERA) system. It is a discretionary grant made as a Cooperative Agreement, which typically means recipients are expected to work closely with CDC staff during the project period. In practice, that cooperative structure is used for programs where federal scientific involvement and coordination across multiple sites is important, such as multi-institution research networks and projects intended to generate broadly applicable prevention approaches.

The program’s scope is explicitly broad in terms of where research can be applied, covering all types of healthcare facilities in the United States. That includes acute-care hospitals as well as other environments where patients receive care and where infections and resistant organisms can be introduced or transmitted. The work supported is oriented toward translation: not only generating knowledge, but turning discoveries into prevention tools, strategies, or practices that can be adopted in real-world clinical operations to reduce HAIs, address AR threats, and prevent related adverse outcomes.

Key administrative details include the Funding Opportunity Number RFA CK 20 004 and CFDA number 93.084, with the funding activity categorized under Health. The anticipated maximum award amount is listed with an award ceiling of $600,000, and the CDC expected to make approximately 11 awards under this announcement. The opportunity was created on December 20, 2019, with an original closing date of March 10, 2020. Applications were required to be submitted electronically, with the deadline specified as no later than 5:00 p.m. Eastern Time on the due date.

Eligibility is intentionally expansive to support participation from a wide range of institutions capable of conducting or supporting applied public health and clinical research. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; and nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories). This wide eligibility reflects the program’s emphasis on building a network that can draw on diverse expertise and settings, including academic, governmental, and community-based organizations that are positioned to study and improve infection prevention and antibiotic resistance mitigation in healthcare.

  • The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Prevention Epicenters Program: Protecting Patients from Infections, Antibiotic Resistance and Other Adverse Events" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
  • This funding opportunity was created on Dec 20, 2019.
  • Applicants must submit their applications by Mar 10, 2020 Electronically submitted applications must be submitted no later than 500 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $600,000.00 in funding.
  • The number of recipients for this funding is limited to 11 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education.
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Frequently Asked Questions (FAQs)

What is the Prevention Epicenters Program?

The Prevention Epicenters Program: Protecting Patients from Infections, Antibiotic Resistance and Other Adverse Events is a CDC funding opportunity intended to build and sustain a collaborative research network that improves patient safety across U.S. healthcare settings. Its focus is on healthcare-associated infections (HAIs), antibiotic resistance (AR), and other harmful events that occur during healthcare.

What is the main goal of this funding opportunity?

The main goal is to connect and coordinate experts working on HAIs and AR so they can rapidly respond to high-priority research needs that matter most for protecting patients. The program supports a shared infrastructure designed to translate research into real-world, evidence-based prevention strategies.

Who is offering and administering this grant?

This opportunity is offered by the U.S. Department of Health and Human Services (HHS), Centers for Disease Control and Prevention (CDC), and it is administered through the CDC electronic research administration (ERA) system.

What type of funding mechanism is this?

This is a discretionary grant made as a Cooperative Agreement. That generally means recipients are expected to work closely with CDC staff during the project period, which aligns with the program's emphasis on federal scientific involvement and coordination across multiple sites.

Why does the announcement emphasize a cooperative agreement structure?

The cooperative structure is commonly used for programs where coordination across multiple institutions and federal scientific involvement are important, such as multi-institution research networks and projects designed to generate broadly applicable prevention approaches.

What kinds of outcomes or impacts is the program trying to achieve?

The program aims to move promising findings from basic science, epidemiology, and technology into practical tools, strategies, or practices that can be adopted in clinical operations to prevent infections, slow the spread of resistant organisms, and reduce other adverse events in healthcare.

What settings can the funded research focus on?

The scope is broad and includes all types of healthcare facilities in the United States. This includes acute-care hospitals as well as other healthcare environments where infections and resistant organisms can be introduced or transmitted.

Is the program focused on basic research or applied/translation work?

The work supported is oriented toward translation. The emphasis is not only on generating knowledge, but on turning discoveries into evidence-based prevention approaches that can be used in real-world healthcare settings.

What are the key identifiers for this funding opportunity?

The Funding Opportunity Number is RFA CK 20 004. The CFDA number is 93.084. The funding activity category is Health.

What is the maximum award amount?

The anticipated maximum award amount (award ceiling) is $600,000.

How many awards does CDC expect to make?

CDC expected to make approximately 11 awards under this announcement.

When was this opportunity posted and when did it close?

The opportunity was created on December 20, 2019, and the original closing date was March 10, 2020.

How were applications required to be submitted?

Applications were required to be submitted electronically through the CDC ERA system.

What was the application deadline time requirement?

The deadline was specified as no later than 5:00 p.m. Eastern Time on the due date.

Who is eligible to apply?

Eligibility is broad and includes the following types of applicants: state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; and nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories).

Why is eligibility so broad for this program?

The broad eligibility reflects the program's emphasis on building a network that draws on diverse expertise and settings. The intent is to include academic, governmental, and community-based organizations positioned to study and improve infection prevention and antibiotic resistance mitigation in healthcare.

Does the program specifically target healthcare-associated infections and antibiotic resistance?

Yes. The program is designed to improve patient safety by addressing healthcare-associated infections (HAIs) and antibiotic resistance (AR), along with other adverse events that occur during healthcare.

What is meant by "other adverse events" in this program description?

The announcement describes the program as focusing on infections, antibiotic resistance, and other harmful events that occur during healthcare, with an overall goal of protecting patients. (No additional categories of adverse events are specified in the provided information.)

What does "shared infrastructure" mean in the context of this program?

Based on the description, shared infrastructure refers to the coordinated network and collaborative framework that connects experts and supports the rapid pursuit of research priorities, helping move findings into practical prevention strategies across healthcare settings.

Is the research limited to a specific type of healthcare facility?

No. The scope explicitly includes all types of healthcare facilities in the United States, including acute-care hospitals and other environments where patient care occurs and infection transmission can happen.

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