Opportunity Information: Apply for CDC RFA CK21 2107
This grant opportunity, titled "Globally coordinated safety monitoring for COVID-19 vaccines" (Funding Opportunity Number: CDC RFA CK21-2107), is a discretionary grant from the U.S. Department of Health and Human Services through the Centers for Disease Control and Prevention (CDC), specifically within NCEZID. Its central purpose is to support large-scale, internationally coordinated monitoring of COVID-19 vaccine safety by leveraging the Global Vaccine Data Network (GVDN), a well-established collaboration designed to study vaccine and biologic impacts at the population level using linked health data.
The program is built around the University of Auckland's Auckland UniServices Limited, identified as the coordinating site for the GVDN. The network includes 21 study sites across 13 countries (Argentina, Australia, Canada, China, Denmark, Finland, France, India, New Zealand, Taiwan, the United Kingdom, the United States, and South Africa), spanning six continents. The CDC description emphasizes that this breadth of geography and population diversity is a major strength, because it allows safety questions to be evaluated across different health systems, demographic groups, and epidemiologic contexts. That kind of heterogeneity is particularly valuable when monitoring newly deployed vaccines, where rare adverse events may only become visible when data are pooled across very large populations.
A key feature of the GVDN is its focus on "big data" methods using large, linked electronic databases to evaluate vaccine safety. The opportunity highlights that each participating site already has experience conducting vaccine safety studies with electronic health records and administrative health datasets, and that many sites also have experience confirming and characterizing potential adverse events through individual medical record review. In practical terms, that means the network can both detect statistical safety signals at scale and, when needed, perform deeper case evaluation to ensure events are correctly identified and classified. The CDC notes that no other existing organization matches the GVDN's combination of geographic diversity, population heterogeneity, subject-matter breadth, and database robustness, and frames these qualities as especially important for the COVID-19 response.
Funding for the opportunity is tied to the Coronavirus Aid, Relief, and Economic Security (CARES) Act, with total funding referenced as $7,000,000. The listing indicates an award ceiling of $5,665,726 and anticipates making a single award (Expected Awards: 1), suggesting a centralized award structure intended to support the coordinating entity and its ability to organize and execute the network's multi-country safety monitoring work. The CFDA number associated with the opportunity is 93.344, and the funding instrument type is a grant under the health activity category.
Administratively, the opportunity was created on March 16, 2021, with an original closing date of March 26, 2021. Applications were required to be submitted electronically by 11:59 p.m. Eastern Time on the due date. Eligibility is listed broadly as "Others," with the expectation that applicants consult the additional eligibility text in the full announcement for precise qualification details. Overall, the grant is aimed at enabling timely, coordinated, and scientifically rigorous vaccine safety surveillance across multiple countries, using established infrastructure and expertise to support public health decision-making during the COVID-19 vaccination effort.Apply for CDC RFA CK21 2107
- The Department of Health and Human Services, Centers for Disease Control - NCEZID in the health sector is offering a public funding opportunity titled "Globally coordinated safety monitoring for COVID-19 vaccines" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.344.
- This funding opportunity was created on Mar 16, 2021.
- Applicants must submit their applications by Mar 26, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $5,665,726.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the title of this grant opportunity?
The grant opportunity is titled "Globally coordinated safety monitoring for COVID-19 vaccines".
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is CDC RFA CK21-2107.
Which agency is offering this grant?
This is a discretionary grant from the U.S. Department of Health and Human Services (HHS) through the Centers for Disease Control and Prevention (CDC), specifically within NCEZID.
What is the main purpose of this funding opportunity?
The central purpose is to support large-scale, internationally coordinated monitoring of COVID-19 vaccine safety by leveraging the Global Vaccine Data Network (GVDN) and its linked health data infrastructure.
What is the Global Vaccine Data Network (GVDN) in the context of this opportunity?
In this opportunity, the GVDN is described as a well-established international collaboration designed to study vaccine and biologic impacts at the population level using large, linked electronic health data.
Who is identified as the coordinating site for the GVDN?
The coordinating site is identified as the University of Auckland's Auckland UniServices Limited.
How many study sites and countries are included in the GVDN network described here?
The network is described as including 21 study sites across 13 countries, spanning six continents.
Which countries are listed as participating in the network?
The listed countries are: Argentina, Australia, Canada, China, Denmark, Finland, France, India, New Zealand, Taiwan, the United Kingdom, the United States, and South Africa.
Why does the CDC emphasize geographic breadth and population diversity?
The CDC emphasizes that broad geography and population diversity allow vaccine safety questions to be evaluated across different health systems, demographic groups, and epidemiologic contexts, which is particularly useful for monitoring newly deployed vaccines.
How does this network help identify rare adverse events?
The opportunity notes that rare adverse events may only become visible when data are pooled across very large populations, which is enabled by multi-country, large-scale linked datasets.
What kind of methods does the opportunity highlight for vaccine safety monitoring?
The opportunity highlights a focus on "big data" methods using large, linked electronic databases such as electronic health records and administrative health datasets to evaluate vaccine safety.
What experience do participating sites already have?
Each participating site is described as already having experience conducting vaccine safety studies using electronic health records and administrative datasets, and many sites also have experience confirming and characterizing potential adverse events through individual medical record review.
Does the opportunity mention any approach beyond statistical signal detection?
Yes. It states that, in addition to detecting statistical safety signals at scale, the network can perform deeper case evaluation via medical record review to ensure events are correctly identified and classified when needed.
How does the CDC describe the uniqueness of the GVDN?
The CDC notes that no other existing organization matches the GVDN's combination of geographic diversity, population heterogeneity, subject-matter breadth, and database robustness for the COVID-19 response.
What is the funding source referenced for this grant?
Funding for the opportunity is tied to the Coronavirus Aid, Relief, and Economic Security (CARES) Act.
What total funding amount is referenced in the listing?
The listing references total funding of $7,000,000.
What is the award ceiling for this opportunity?
The award ceiling is listed as $5,665,726.
How many awards are expected to be made?
The opportunity anticipates making a single award (Expected Awards: 1).
What does an expected single award suggest about the structure of this program?
Based on the listing, the expected single award suggests a centralized award structure intended to support a coordinating entity that can organize and execute the network's multi-country safety monitoring work.
What is the CFDA number associated with this opportunity?
The CFDA number associated with this opportunity is 93.344.
What is the funding instrument type?
The funding instrument type is a grant under the health activity category.
When was the opportunity created?
The opportunity was created on March 16, 2021.
What was the original closing date for applications?
The original closing date was March 26, 2021.
How were applications required to be submitted?
Applications were required to be submitted electronically.
What was the application submission deadline time?
Applications were due by 11:59 p.m. Eastern Time on the due date.
Who is eligible to apply, based on the listing?
Eligibility is listed broadly as "Others".
Where should applicants look for precise eligibility requirements?
The listing indicates that applicants should consult the additional eligibility text in the full announcement for precise qualification details.
What public health need is this grant intended to support?
The grant is aimed at enabling timely, coordinated, and scientifically rigorous vaccine safety surveillance to support public health decision-making during the COVID-19 vaccination effort.
What types of data are central to the described surveillance approach?
The approach centers on large, linked electronic databases, including electronic health records and administrative health datasets across participating sites.
Is this opportunity focused on a domestic U.S. program or an international program?
Based on the description, it is explicitly designed as an internationally coordinated program spanning multiple countries and continents.
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